FIGURE 2.

RORα regulates NPAS2 mRNA expression. a, infection of HepG2 cells with an adenovirus directing the expression of RORα results in overexpression of the receptor. b, overexpression of RORα results in induction of NPAS2 expression in HepG2 cells. c, treatment of HepG2 cells with siRNA directed at RORα suppresses expression of the receptor. d, suppression of RORα expression results in significantly lower expression of NPAS2. Data are presented as the mean ± S.E. Student's t test was used to compare the control cells to the RORα overexpressed or knocked down cells. * indicates a p value <0.05.