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. 2010 Sep 15;285(46):35783–35791. doi: 10.1074/jbc.M110.155663

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Role of Leu-125 in the undamaged DNA and lesion recognition complexes. A, the LRC of AlkA with a space-filling model of Leu-125 (blue) and the nucleobases (yellow) that are in van der Waals contact. B, view of the minor groove of the UDC with Leu-125 and the interrogated base C20 shown as a space-filling model. C, same view as in B, with the base of m3A modeled in place of C20. The N3-methyl group is shown in orange. D, same view as in C, with Leu-125 and the base of m3A shown as a space-filling model, illustrating the van der Waals contact between the Leu-125 side chain and the N3-methyl adduct (orange).