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SPR analysis. SPR analysis of the binding of SPI (A), Stat3 SH2 domain (B), or full-length Stat3 (C) to GpYLTQTV-NH2 (high affinity IL-6R/gp-130 peptide), PpYLKTK (Stat3 pTyr peptide), GpYIKTE (Stat1 pTyr peptide), GpYVKPQ (Stat5 pTyr peptide), PEpYINQS (EGFR pTyr peptide), PVpYHNQP (EGFR pTyr peptide), and S3I-201 (Stat3 dimerization inhibitor). Data are representative of three independent determinations.
