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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Trends Biochem Sci. 2010 May 7;35(9):490–496. doi: 10.1016/j.tibs.2010.04.004

Figure 1. Role of JNK1 in adipocytes.

Figure 1

Feeding a high fat diet (HFD) causes JNK1 activation in adipocytes, leading to insulin resistance in adipocytes and expression of the adipokine IL6. JNK-mediated phosphorylation of IRS1 might contribute to insulin resistance in adipocytes. The increased concentration of IL6 in the blood up-regulates expression of SOCS3, a protein that targets IRS1 for ubiquitin-mediated degradation and hepatic insulin resistance.