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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Trends Biochem Sci. 2010 May 7;35(9):490–496. doi: 10.1016/j.tibs.2010.04.004

Figure 2. Role of JNK1 in muscle.

Figure 2

Feeding a high fat diet (HFD) causes JNK1 activation in muscle and insulin resistance. Loss of JNK1 causes decreased expression of lipoprotein lipase (LPL), an enzyme that promotes absorption of triglycerides (e.g. VLDL; very low density lipoprotein). Increased accumulation of fatty acids (FFA) and increased phosphorylation of IRS1 might contribute to JNK1-mediated insulin resistance.