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Plk2-deficient cells are chemoresistant under hypoxia and chemosensitive under normoxia in vitro. Plk2 deficient or control H460 cells were treated with camptothecin (0, 100 or 200 μg; 22 hrs includes 2.5 hrs pre-hypoxia) and hypoxia (0.2% oxygen, 19 hrs) or normoxia. Cells were harvested, fixed and stained with propidium iodide and analyzed by flow cytometry for sub-G1 DNA content.
