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Model specification
| Latent variable | Causative polymorphism | Noncausal marker | Phenotype | Genotype frequency |
|---|---|---|---|---|
| 0 | 0 | 0 | 0 | a |
| 0 | 0 | 1 | 0 | b |
| 0 | 1 | 0 | βC | c |
| 0 | 1 | 1 | βC | d |
| 1 | 0 | 0 | βL | e |
| 1 | 0 | 1 | βL | f |
| 1 | 1 | 0 | βC + βL + βLC | g |
| 1 | 1 | 1 | βC + βL + βLC | h |
The model is defined as a “genotype” of three binary factors, L, C, and N. Every combination of these factors perfectly describes a phenotype P and occurs with a frequency indicated by a, … , h. Table 2 defines some useful parameterizations.
