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. Author manuscript; available in PMC: 2010 Nov 8.
Published in final edited form as: Neurosci Lett. 2006 Mar 22;401(1-2):130–135. doi: 10.1016/j.neulet.2006.03.001

Table 1.

Parkin protects from tau-induced loss of dopamine neurons

Group Dose (particles) N TH neurons Comparison
Uninjected – 5 9682 ± 143
Tau/GFP AAV 2 × 1010 9 7495 ± 558 P < 0.01 Tau/Parkin or uninjected
Tau/Parkin AAV 2 × 1010 9 9264 ± 335 N.S. uninjected

Number of SN pars compacta neurons (±S.E.M.) immunoreactive for tyrosine hydroxylase (TH) estimated by stereology 5 weeks after injections in the case of the AAV vector groups. The tau/GFP was injected on the side contralateral to the tau/parkin in nine animals. There were fewer cells on the tau/GFP side relative to the tau/parkin side (paired t-test, P < 0.01). When an uninjected group was compared, there were fewer cells in the tau/GFP group relative to control but not in the tau/parkin group (ANOVA and Dunnett's multiple comparison test, P < 0.01).