Fig. 29.

Liver homograft rejection in animals treated with azathioprine. In dogs that died 1–2 weeks after operation, pathologic changes are similar to those with homotransplantation to the unmodified recipient, differing only in that the sequence of destruction is delayed. A, treated canine hepatic homograft, undergoing rejection at 7 days. Portal tract is heavily infiltrated by mononuclear cells. Outlined rectangular area is shown in greater detail in B. Hematoxylin-eosin; ×250. B, details of cellular infiltration in portal tract of hepatic homograft in A. Many of the cells are large blast cells with several nucleoli and pyronin-positive cytoplasm; one is in mitosis (arrow). Hematoxylin-eosin; ×600. C, treated hepatic homograft at 8 days. A plasma cell with abundant rough endoplasmic reticulum in its cytoplasm is seen in a portal tract. Electron micrograph; × 2,400.