Fig. 30.

Unsuccessful control of rejection after orthotopic liver transplantation. A, hepatic homograft rejected in 15 days despite azathioprine treatment. There is widespread destruction of hepatocytes in central and middle zones of the lobules. Only a rim of liver cells remains around the small portal tract (arrow), which is heavily infiltrated by mononuclear cells. Hematoxylin-eosin; ×40. B, early distortion of architecture resulting from canine liver rejection in the modified host. These changes determine the pattern of healing in animals which survive this critical period. Centrilobular loss of hepatocytes has been followed by collapse and condensation of reticulin around the central vein (arrow). P, portal tract. Reticulin stain; ×40.