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. Author manuscript; available in PMC: 2010 Nov 8.

Published in final edited form as: Adv Surg. 1966;2:295–370.

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Fig. 47 — Case 2 of Colorado series: treated human orthotopic hepatic homograft at 22 days. A, B and C show typical appearance of the tissue; D–F show most severely damaged porting, these necrotic areas being focal and uncommon. A, centers of lobules appear dark because the hepatocytes contain excess lipofuscin. Increase of portal connective tissue was probably present before homotransplantation. There is patchy cellular infiltration, particularly in smaller portal tracts. Hematoxylin-eosin; ×20. B, lobular architecture is essentially normal. Reticulin stain; ×20. C, portal tract is infiltrated by mononuclear cells. There is proliferation of small bile ducts. Hematoxylin-eosin; ×250. D, area in which whole lobules have undergone necrosis, being replaced by collagen and reticulin fibers, many small bile ducts and foci of infiltrating mononuclear cells. Hematoxylin-eosin; ×20. E, area of massive necrosis. Reticulin has collapsed, destroying normal lobular pattern. Reticulin stain; ×20. F, massive necrosis has occurred and hepatocytes are now replaced by collagen and reticulin fibers, proliferating bile ducts and foci of infiltrating mononuclear cells. Hematoxylin-eosin; ×250.

Fig. 47 — Case 2 of Colorado series: treated human orthotopic hepatic homograft at 22 days. A, B and C show typical appearance of the tissue; D–F show most severely damaged porting, these necrotic areas being focal and uncommon. A, centers of lobules appear dark because the hepatocytes contain excess lipofuscin. Increase of portal connective tissue was probably present before homotransplantation. There is patchy cellular infiltration, particularly in smaller portal tracts. Hematoxylin-eosin; ×20. B, lobular architecture is essentially normal. Reticulin stain; ×20. C, portal tract is infiltrated by mononuclear cells. There is proliferation of small bile ducts. Hematoxylin-eosin; ×250. D, area in which whole lobules have undergone necrosis, being replaced by collagen and reticulin fibers, many small bile ducts and foci of infiltrating mononuclear cells. Hematoxylin-eosin; ×20. E, area of massive necrosis. Reticulin has collapsed, destroying normal lobular pattern. Reticulin stain; ×20. F, massive necrosis has occurred and hepatocytes are now replaced by collagen and reticulin fibers, proliferating bile ducts and foci of infiltrating mononuclear cells. Hematoxylin-eosin; ×250.