. Author manuscript; available in PMC: 2010 Nov 8.

Published in final edited form as: FASEB J. 2008 Jan 9;22(6):2090–2096. doi: 10.1096/fj.07-098178

TABLE 1. Effect of 4 wk of CR or ADF on circulating hormones and growth factors.

Hormone or growth factor	Control	CR-25%	ADF-75%	ADF-85%	ADF-100%
IGF-1 (ng/ml)	359 ± 52*	197 ± 18^#	303 ± 39*	270 ± 44*	190 ± 19^#
IGFBP-3 (ng/ml)	9.07 ± 1.21	8.16 ± 1.14	8.29 ± 0.91	7.92 ± 0.95	7.78 ± 0.87
Total ghrelin (pg/ml)^a	1003 ± 181	1229 ± 125	1244 ± 91	995 ± 101	1283 ± 140
Oct ghrelin (pg/ml)^a	155 ± 27*	160 ± 19*	191 ± 79*	187 ± 63*	292 ± 64
Des ghrelin (pg/ml)^a	847 ± 188	1068 ±144	1053 ± 30	807 ± 88	991 ± 91

Values are expressed as means ± SE. Means not sharing a common symbol are significantly different (P<0.05; one-way ANOVA with Tukey post hoc test for IGF-1; t test for ghrelin).

Ghrelin levels were analyzed in a subset of mice (n=3 per group), whereas IGF-1 and IGFBP-3 levels were analyzed in all mice (n=6 per group).