Table 2.

Expression pattern, interacting co-factors, effect on gene expression and known functions of different KLFs.

Gene	Expression pattern	Interacting co-factors	Cellular function	References
KLF1	Erythroid and mast cells	P300/CBP, PCAF, SWI.SNF and mSin3A	Erythropoiesis, cell cycle	[25,26]
KLF2	Lung, blood vessels, lymphocytes	WWP1	Adipogenesis, lung and blood vessel development, T-cell migration, monocyte activation	[27-30]
KLF3	Adipocytes, brain and erythroid tissue	CtBP2, FHL3	Adipogenesis	[31,32]
KLF4	Gut, skin, cornea and several other epithelial tissues	HDAC, p300/CBP, b-catenin/TCF4, Oct4, Sox2, CtBP	Epithelial barrier formation, goblet cell development, adipogenesis, stem cell maintenance, control of cell proliferation, regulation of neuronal regeneration	[33-39]
KLF5	Gut, skin, lung, cornea and several other epithelial tissues	P53, HDAC1, PARP1, PIAS1	Cell growth, lung development, cardiac remodelling, stem cell maintenance	[40-45]
KLF6	Ubiquitous	HDAC3	Tumour suppressor	[46]
KLF7	Ubiquitous	MoKA	Cell proliferation, neuronal differentiation, olfactory bulb development	[47-51]
KLF8	Ubiquitous	CtBP2	Cell proliferation, epithelial to mesenchymal transition	[52-55]
KLF9	Ubiquitous	mSin3A	Neurite outgrowth, carcinogen metabolism, intestinal epithelial development	[56-58]
KLF10	Ubiquitous	mSin3A	Apoptosis, cell proliferation	[22,59]
KLF11	Ubiquitous	mSin3A, p300	Cell proliferation	[60,61]
KLF12	Brain, kidney, liver and lung	CtBP1	Cancer progression	[62,63]
KLF13	Ubiquitous	mSin3A, p300, PCAF	Cell proliferation, carcinogen metabolism	[64,65]
KLF14	Ubiquitous	mSin3A, HDAC2	Lipoprotein metabolism, basal cell carcinoma, TGF-β signalling	[66-68]
KLF15	Ubiquitous	Sp1, MEF2A	Cardiomyocyte hypertrophy, gluconeogenesis	[69-71]
KLF16	Ubiquitous	mSin3A	Carcinogen metabolism, cell cycle	[65,72]
KLF17	Testis, brain and bone	Not known	Epithelial-mesenchyme transition	[73,74]

Key

TGF-β, transforming growth factor-beta.