Table I.
Differential impact of CD154 blockade on KEGG pathways in naive vs. sensitized cardiac allograft recipients
| KEGG Pathway | Array | Naive |
Sensitized |
||
|---|---|---|---|---|---|
| List | z-score | List | z-score | ||
| TCR signaling pathway | 11 | 16 | 1.94 | 3 | −2.13 |
| Cell adhesion molecules | 129 | 26 | 3.77 | 11 | −0.49 |
| NK cell-mediated cytotoxicity | 112 | 22 | 2.32 | 0 | −0.13 |
| Cell communication | 108 | 21 | 2.0 | 14 | 1.13 |
| Calcium signaling pathway | 100 | 26 | 2.42 | 28 | 3.14 |
| Olfactory transduction | 29 | 12 | 5.21 | 5 | 1.36 |
| Neuroactive ligand-receptor interaction | 26.8 | 54 | 4.89 | 60 | 7.21 |
| Maturity onset diabetes of the young | 25 | 7 | 2.7 | 10 | 5.1 |
| γ-Hexachlorocyclohexane degradation | 23 | 6 | 2.29 | 5 | 1.94 |
| Basal cell carcinoma | 55 | 6 | −0.05 | 15 | 4.4 |
| Metabolism of xenobiotics by cytochrome P450 | 59 | 7 | −0.05 | 15 | 4.48 |
| Androgen and estrogen metabolism | 38 | 7 | 1.44 | 9 | 2.9 |
| Wnt signaling pathway | 14.2 | 14 | −0.48 | 22 | 2.34 |