Table III.
Fifty highly expressed immune-related genes in cardiac allografts altered by CD154 blockade in naive, but not sensitized recipients
| Gene | Expression Levels |
|||
|---|---|---|---|---|
| 1 (N) | 2 (N/MR1) | 3 (S) | 4 (S/MR1) | |
| Chemokine (C-C motif) ligand 5 | 16.49 | 5.14 | 19.59 | 21.94 |
| Fc receptor, IgE, high-affinity I, γ-polypeptide | 15.03 | 7.53 | 17.74 | 18.42 |
| Integrin β2 | 12.02 | 4.61 | 13.04 | 14.39 |
| Histocompatibility 2, Q region locus 8 | 11.83 | 5.05 | 10.93 | 10.83 |
| Chemokine (CXC motif) ligand 10 | 10.93 | 3.47 | 8.29 | 7.80 |
| Fc receptor, IgG, low-affinity IV | 10.14 | 4.01 | 12.65 | 12.11 |
| IL-2R, γ-chain | 9.56 | 3.33 | 8.27 | 8.47 |
| Fc receptor, IgG, low-affinity III | 8.42 | 4.73 | 11.06 | 11.57 |
| Killer cell lectin-like receptor, subfamily D, member 1 | 8.22 | 1.51 | 6.46 | 6.29 |
| RAS-related C3 botulinum substrate 2 | 6.89 | 2.00 | 5.01 | 5.04 |
| Selectin, platelet (P-selectin) ligand | 5.64 | 1.79 | 4.27 | 4.07 |
| Integrin αL | 5.02 | 1.77 | 4.77 | 4.41 |
| Killer cell lectin-like receptor subfamily K, member 1 | 4.86 | 1.16 | 4.29 | 4.31 |
| Lymphotoxin B | 4.75 | 1.22 | 3.24 | 3.33 |
| IL-18R1 | 4.71 | 0.99 | 4.52 | 4.83 |
| Fc receptor, IgG, high-affinity I | 4.63 | 2.00 | 5.49 | 5.42 |
| Integrin α4 | 4.57 | 1.12 | 3.14 | 3.37 |
| Histocompatibility 2, class II, locus Mb2 | 4.35 | 2.39 | 4.90 | 5.32 |
| Lymphocyte cytosolic protein 2 | 4.20 | 1.64 | 4.11 | 4.02 |
| FBJ osteosarcoma oncogene | 3.59 | 1.28 | 4.70 | 4.93 |
| CD8 Ag, α-chain | 3.52 | 0.64 | 3.02 | 3.03 |
| Chemokine (CXC motif) ligand 9 | 3.21 | 1.12 | 3.48 | 3.90 |
| IL-1β | 2.98 | 0.96 | 3.40 | 5.48 |
| Histocompatibility 2, class II, locus Mb1 | 2.86 | 1.38 | 3.70 | 2.86 |
| Casitas B-lineage lymphoma b | 2.48 | 0.80 | 1.72 | 1.99 |
| Chemokine (C-C motif) receptor 5 | 2.46 | 0.74 | 2.73 | 2.87 |
| Chemokine (C-C motif) receptor 1 | 2.44 | 0.72 | 3.14 | 3.27 |
| IL-6 | 2.41 | 0.49 | 2.98 | 3.07 |
| TNFR superfamily, member 1b | 2.27 | 1.09 | 2.47 | 2.65 |
| PI3K catalytic δ-polypeptide | 2.24 | 0.64 | 1.54 | 1.85 |
| CD40 Ag | 2.18 | 0.81 | 1.69 | 1.71 |
| CD44 Ag | 2.03 | 0.63 | 2.10 | 2.47 |
| Selectin, lymphocyte | 2.03 | 0.54 | 1.49 | 1.49 |
| Programmed cell death 1, ligand 2 | 1.94 | 0.20 | 1.90 | 2.02 |
| Fas ligand (TNF superfamily, member 6) | 1.67 | 0.24 | 1.32 | 1.47 |
| Integrin β7 | 1.59 | 0.50 | 1.29 | 1.66 |
| CD38 Ag | 1.58 | 0.35 | 1.84 | 1.51 |
| BH3-interacting domain death agonist | 1.55 | 0.65 | 1.41 | 1.28 |
| CD86 Ag | 1.53 | 0.83 | 2.29 | 1.68 |
| RAS guanyl-releasing protein 1 | 1.49 | 0.67 | 1.26 | 1.37 |
| IL-18R accessory protein | 1.44 | 0.35 | 1.71 | 1.53 |
| Bone morphogenetic protein 2 | 1.41 | 0.48 | 2.09 | 1.35 |
| PTK2 protein tyrosine kinase 2β | 1.39 | 0.53 | 1.33 | 1.27 |
| Colony-stimulating factor 2 receptor, β 2, low affinity | 1.24 | 0.57 | 1.84 | 2.22 |
| Syndecan 4 | 1.21 | 0.68 | 1.92 | 1.82 |
| CD1d1 Ag | 1.17 | 0.50 | 1.35 | 1.63 |
| Colony-stimulating factor 3 receptor (granulocyte) | 1.13 | 0.56 | 1.61 | 1.85 |
| Vav 1 oncogene | 1.08 | 0.32 | 0.92 | 0.68 |
| IL-10Rα | 1.02 | 0.53 | 1.26 | 1.02 |
| CD6 Ag | 1.01 | 0.29 | 0.73 | 0.86 |
| CD4 Ag | 0.019 | 0.0064 | 0.021 | 0.046 |