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. Author manuscript; available in PMC: 2011 Oct 31.
Published in final edited form as: Respir Physiol Neurobiol. 2010 Feb 17;173(3):223–229. doi: 10.1016/j.resp.2010.02.006

Figure 3. Vigilance-state-dependent changes in hypercapnic ventilatory responsiveness in wild-type (WT) mice and prepro-orexin knockout mice (ORX-KO).

Figure 3

Hypercapnic responsiveness was evaluated by calculating the slope of the relationship between the inspired CO2 concentration (0-10%) and minute ventilation. Data are presented as means ± SEM of 5 WT mice and 5 ORX-KO mice. * P < 0.05 compared with WT mice. † P < 0.05 compared with the data during awake (ANOVA with repeated measures design). Abbreviations: SWS, slow-wave sleep; REM, rapid-eye-movement sleep. (Adapted from (Nakamura et al. 2007))