Table 3.
Onset of GVHD and survival
| Group | Therapy | Mg/kg/day i.m. | Days of therapy after BM | % With GVHD | GVHD median days to onset | Days surviving | Mean survival time | P | Versus group |
|---|---|---|---|---|---|---|---|---|---|
| 1 | None | — | — | — | — | 11, 11, 12, 13, 13 | 12.0 | ||
| 2 | None | — | — | — | — | all >60 | >60 | ||
| 3 | None | — | — | 100 | 10 | 17, 19, 19, 20, 20, 20, 22, 24, 25, 25 | 21.1 | ||
| 4 | CsA | 15 | 3–9 | 100 | 17 | 22, 31, 31, 31, 31, 31, 31, 31, 31, 32 | 30.2 | <0.005 | 3 |
| 5 | CsA | 25 | 3–9 | 100 | 25 | 25, 28, 32, 32, 32, 32, 32, 32, 32, 39 | 31.6 | <0.005 | 3 |
| 6 | FK506 | 1 | 3–9 | 70 | 50 | 38, 51, 52,a 52, 52, 52, | 52.3 | <0.005 | 4 |
| 52, 54, >60, >60 | <0.005 | 5 | |||||||
| 7 | FK506 | 1 | 3–9, then 0.1 mg/kg | 0 | — | ALL >60 (n = 3) | >60 | <0.005 | 6 |
| 8 | FK506 | 0.1 | 3–16 | 100 | 25 | 31, 31, 31, 31, 31, 31, 31, 31, 31, 31 | 31 | <0.005 | 3 |
| 9 | FK506 | 1.0 | 3–16 | 90 | 52 | 46, 52,a58,a 58,a 58, 58, 58, 58, 58, >60 | 56 | <0.005 | 7 8 |
| 10 | FK506 | 1.5 | 3–16 | 10 | 58 | 58, >60, >60, >60, >60, >60, >60, >60, >60, >60 | >60 | — | 11 |
a
Animals died without clinical symptoms of GVHD.