Table I.
Lipid metabolism genes upregulated (at least two-fold) in P311-stable C3H10 cells
| Function | Symbol | Gene name | Fold increase |
|---|---|---|---|
|
Sterol /Steroid Biosynthesis |
CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 |
4.20 |
| Dhcr24 | 24-dehydrocholesterol reductase | 2.31 | |
| EBP | emopamil binding protein | 2.43 | |
| FDPS | farnesyl diphosphate synthase | 3.43 | |
| Hmgcs1 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 | 3.53 | |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 2.75 | |
| IDI1 | isopentenyl-diphosphate delta isomerase | 11.71 | |
| LSS | lanosterol synthase | 2.77 | |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 3.10 | |
| Sc4mol | sterol-C4-methyl oxidase-like | 4.32 | |
| Sc5d | sterol-C5-desaturase | 2.95 | |
| Stard4 | StAR-related lipid transfer (START) domain contain. 4 | 4.72 | |
|
Synthesis of triglycerols |
DGAT2 | Diacylglycerol acyltransferase 2 | 2.77 |
|
Transport and Internalization of lipid |
ABCD3 | ATP-binding cassette sub-family D (ALD) member 3 | 2.20 |
| CROT | carnitine O-octanoyltransferase | 2.00 | |
| FAAH | fatty acid amide hydrolase | 3.07 | |
|
Accumulation of cholesterol/ cholesterol ester |
ACAT2 | acetyl-Coenzyme A acetyltransferase 2 | 2.53 |
| LDLR | low density lipoprotein receptor | 2.57 | |
|
Prevention of oxidation |
CAT | catalase | 3.97 |
| GSTA2 | glutathione S-transferase A2 | 7.41 | |
| MT1A | metallothionein 1A | 2.93 | |
| MT2A | metallothionein 2A | 2.07 |