Skip to main content
. Author manuscript; available in PMC: 2011 Oct 1.
Published in final edited form as: Physiol Rev. 2010 Oct;90(4):1337–1381. doi: 10.1152/physrev.00058.2009

Figure 2. Protein structure of human KLF family members.

Figure 2

KLF proteins are grouped according to common structural and functional domains. KLFs are highly homologous in their carboxyl-terminal DNA-binding regions, which contain three C2H2 zinc finger motifs. The family members were grouped based on: (1) the ability to bind acetylases (KLFs 1, 2, 4, 5, 6, and 7); (2) the presence of a CtBP-binding site (KLFs 3, 8, and 12); or (3) the presence of a Sin3A-binding site (KLFs 9, 10, 11, 13, 14, and 16). Established sites of acetylation are marked by stars.