Figure 5. Contribution of KLFs in regulating adipocyte differentiation.
Pre-adipocytes progress through an early stage of differentiation in which they become committed to their fate, followed by a late stage of terminal differentiation into mature adipocytes. Various members of the KLF family contribute to transcriptional control of this process and have positive and negative effects on adipogenesis [Adapted from Nagai, Friedman and Kasuga, Editors (294)].