Table 5.

Summary results of significant individual haplotypes associated with alcohol dependence comorbid with drug dependence (AD+DD) in the ANKK1 and DRD2 regions.

SNP#	A3	A4	A5	A6	A7	D1	D2	D3	# of fam b	Hap-freqc				t-stat/Zd	I-hap pe	Global p
Allelesa	C/T	G/A	C/T	C/G	G/A	A/G	A/G	G/A		pooled	control	case	diff
Case-control		G	C	G					---	0.30	0.28	0.35	0.07	3.01	0.0028	0.022
			C	G	G				---	0.29	0.27	0.34	0.07	2.99	0.0029	0.039
	C	G	C	G					---	0.13	0.12	0.16	0.04	2.81	0.0051	0.020
		G	C	G	G				---	0.28	0.27	0.33	0.06	2.76	0.0060	0.015
			C	G	G	G			---	0.28	0.27	0.34	0.07	2.77	0.0058	0.024
		G	C	G	G	G				0.28	0.27	0.33	0.06	2.63	0.0087	0.020
Family					G	G	G		34	0.24	---	---	---	2.40	0.017	0.042
						G	G	G	34	0.24	---	---	---	2.76	0.0059	0.048
				G	G	G	G		30	0.24	---	---	---	2.73	0.0064	0.027
					G	G	G	G	33	0.24	---	---	---	2.59	0.0096	0.015
				G	G	G	G	G	29	0.24	---	---	---	2.60	0.0093	0.037

^aThe allele listed on top is the common allele. Black square with white alleles in a row denotes risk haplotypes.

^bNumber of informative families.

^cHaplotype frequency for the pooled (combined the case and control samples for the case-control design, but representing overall estimates of haplotype frequency for the family design), control, case, and the difference between cases and controls.

^d“t-stat” is the t-statistic calculated for the case-control sample, and “Z” for the family sample.

^eIndividual haplotype p-value.