Table 6.

Summary results of significant individual haplotypes associated with AD+DD in the NCAM1 region.

SNP#		N6	N7	N8	N9	N10	N11	N12	N13	# of famb	Hap-freqc	t-stat/Zd	I-hap pe	Global p
Allelesa		A/G	T/C	G/T	C/A	A/C	T/C	T/C	T/G
Family	3-, 4- or 5-SNP haplotypes			G	A	A				25.1	0.12	2.91	0.0036	0.016
				T	C	A				52	0.40	−2.45	0.014	0.016
					C	A	T			37	0.42	−2.40	0.016	0.0040
			T	T	C	A				45.4	0.38	−2.82	0.0048	0.011
				T	C	A	T			30.8	0.24	−2.58	0.0098	0.0056
					C	A	T	T		37.8	0.37	−2.43	0.015	0.0049
		A	T	T	C	A				44.4	0.38	−2.98	0.0029	0.0074
			T	T	C	A	T			27.2	0.22	−2.90	0.0037	0.0014
				T	C	A	T	T		28.3	0.23	−2.55	0.011	0.027
					C	A	T	T	T	36.8	0.36	−2.90	0.0038	0.0035

^aThe allele listed on top is the common allele. Black square with white alleles in a row denotes risk haplotypes, while white square with black alleles in a row denotes protective haplotypes.

^bNumber of informative families.

^cHaplotype frequency for the pooled (combined case and control samples for the case-control design, but representing overall estimates of haplotype frequency for the family design), control, case, and the difference between cases and controls.

^d“t-stat” is the t-statistic calculated for the case-control sample, and “Z” for the family sample.

^eIndividual haplotype p-value.