Table 1.
Study Sample Characteristics
| Stage 1 Samples (Discovery) |
Stage 2 Samples (Replication) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular Health Study | Rotterdam Study | KORA | Framingham Heart Study | Gutenberg Heart Study | Study of Health in Pomerania | Austrian Stroke Prevention Study | ||||||||
|
Clinical Characteristics | ||||||||||||||
| No. with echocardiography | 3279 | 2199 | 589 | 3245 | 3300 | 3212 | 882 | |||||||
| Age, mean (SD), y | 75 (5) | 75 (6) | 52 (10) | 52 (10) | 56 (11) | 54 (14) | 66 (7) | |||||||
| Female sex, No. (%) | 2000 (61) | 1341 (61) | 324 (55) | 1752 (54) | 1617 (49) | 1734 (54) | 503 (57) | |||||||
| Physical characteristics, mean (SD) | ||||||||||||||
| Height, cm | 165 (9) | 166 (9) | 168 (9) | 168 (9) | 171 (9) | 169 (9) | 166 (9) | |||||||
| Weight, kg | 72 (14) | 76 (13) | 75 (13) | 76 (16) | 79 (16) | 79 (16) | 74 (13) | |||||||
| Systolic BP, mm Hg | 135 (19) | 154 (21) | 133 (19) | 125 (15) | 134 (18) | 136 (21) | 144 (23) | |||||||
| Hypertension, No. (%) | 1246 (38) | 902 (41) | 106 (18) | 552 (17) | 462 (14) | 803 (25) | 309 (35) | |||||||
| Smoking, No. (%) | 361 (11) | 286 (13) | 112 (19) | 746 (23) | 594 (18) | 867 (27) | 97 (11) | |||||||
| Echocardiographic Characteristics | ||||||||||||||
| Echocardiographic traits, mean (SD) | Men | Women | Men | Women | Men | Women | Men | Women | Men | Women | Men | Women | Men | Women |
| LV mass, g | 172 (48) | 133 (35) | 162 (47) | 133 (36) | 186 (40) | 145 (37) | 185 (33) | 137 (24) | 212 (57) | 152 (43) | 218 (59) | 163 (53) | 224 (61) | 175 (57) |
| LV diastolic dimensions, cm | 5.1 (0.6) | 4.7 (0.5) | 5.3 (0.5) | 4.9 (0.5) | 5.0 (0.4) | 4.6 (0.4) | 5.1 (0.3) | 4.6 (0.3) | 4.7 (0.5) | 4.3 (0.4) | 5.2 (0.5) | 4.8 (0.5) | 4.9 (0.6) | 4.5 (0.5) |
| LV wall thickness, cm | 1.8 (0.3) | 1.7 (0.2) | 1.7 (0.3) | 1.6 (0.3) | 2.0 (0.3) | 1.8 (0.3) | 2.0 (0.2) | 1.8 (0.2) | 2.1 (0.3) | 1.9 (0.3) | 2.2 (0.4) | 1.9 (0.4) | 2.3 (0.4) | 2.1 (0.4) |
| Left atrial size, cm | 4.1 (0.8) | 3.8 (0.6) | 4.2 (0.6) | 3.9 (0.6) | 4.0 (0.4) | 3.7 (0.5) | 4.0 (0.4) | 3.6 (0.4) | NA | NA | 3.8 (0.6) | 3.4 (0.6) | 4.0 (0.6) | 3.7 (0.6) |
| Aortic root, cm | 3.5 (0.6) | 3.0 (0.3) | 3.6 (0.4) | 3.2 (0.4) | 3.1 (0.4) | 2.7 (0.4) | 3.4 (0.3) | 2.9 (0.2) | NA | NA | 3.3 (0.4) | 2.8 (0.4) | 3.2 (0.4) | 2.9 (0.4) |
| LV systolic dysfunction, No. (%) | 237 (7) | 266 (12) | 48 (8) | 159 (5) | 165 (5) | 405 (13) | 111 (13) | |||||||
Abbreviations: BP, blood pressure; KORA, Cooperative Health Research in the Region of Augsburg study; LV, left ventricular; NA, not available in Gutenberg Heart Study.