. Author manuscript; available in PMC: 2011 Nov 10.

Published in final edited form as: J Am Chem Soc. 2010 Nov 10;132(44):15800–15807. doi: 10.1021/ja1071509

Table 2.

Reaction scope of pyrroles with vinyl aziridines^a


3a 99% yield, 89% ee	3b 77% yield, 89% ee	3c 76% yield, 96% ee
3d 86% yield, 94% ee	3e 86% yield, 94% ee	3f 92% yield, 93% ee
3g 95% yield, 93% ee	3h 85% yield, 90% ee^b	3i, R = Et: NR 3j, R = H: NR

All reactions were performed with 1.0 equiv of pyrrole nucleophile and 1.1 equiv of 1 at ambient temperature. Isolated yield. % ee was determined by chiral HPLC.

1.1 equiv of Cs₂CO₃ was added.