. Author manuscript; available in PMC: 2011 Nov 10.

Published in final edited form as: J Am Chem Soc. 2010 Nov 10;132(44):15800–15807. doi: 10.1021/ja1071509

Table 3.

Reaction scope of indoles with vinyl aziridines^a


4a 89% yield, 90% ee^b	4b 96% yield, 92% ee	4c 99% yield, 86% ee
4d 86% yield, 88% ee	4e 92% yield, 89% ee	4f 88% yield, 90% ee
4g 81% yield, 83% ee	4h 99% yield, 81% ee^b	4i 91% yield, 93% ee
4j 57% yield, 73% ee^b	4k 60% yield, 73% ee^b	4l, R = H: NR 4m, R = Ph: NR

All reactions were performed with 1.0 equiv of indole nucleophile and 1.1 equiv of 1 at ambient temperature. Isolated yield. % ee was determined by chiral HPLC.

1.1 equiv of Cs₂CO₃ was added.