Table 3.

Clinical Features of 25 Children Given Treatment with the DAC Regimen

No.	Disease Stage	Sites of Disease	Pathology	Response
				DAC	DAC + CHOD	Relapse	Status
1	III	Bones, soft tissue	DLBCL	CR*	--	--	A
2	III	Lymph nodes	DLBCL	CR	--	--	A
3	III	Mediastinum, lung	MLBCL	PR	PR	Mediastinum	A
4	IIIa	Intestine	DLBCL	CR	--	--	A
5	III	Mediastinum, lymph nodes	LC-T,NOS	PRb	PRc	--	D
6	III	Mediastinum, bone, pancreas	LC-T,NOS	CR	--	--	A
7	III	Skin, lymph nodes, bone	ALCL	PRc	--	--	A
8	III	Mediastinum, bones, lymph nodes, soft tissue	ALCL	PR	CR*	Bones, lung	D
9	III	Mediastinum, abdominal mass, lymph nodes	ALCL	PR	CR*	--	A
10	III	Paraspinal mass, bones	ALCL	PR	PRc	--	D
11	III	Mediastinum, soft tissue, bone	ALCL	NRc	--	--	D
12	III	Lymph nodes, pleural mass	ALCL	NR(mixed)c	--	--	A
13	III	Lung, lymph nodes, skin, bones	ALCL	CR	--	--	A
14	IV	Lymph nodes, bone, spleen, bone marrow	ALCL	CR*	--	--	A
15	III	Lymph nodes, spleen	ALCL	CR*	--	--	A
16	III	Lymph nodes, spleen	ALCL	CR	--	--	A
17	III	Lymph nodes	ALCL	CR	--	--	A
18	III	Bones, mediastinum, skin, lymph nodes, kidney	ALCL	CR	--	Skin, lymph node	D
19	III	Mediastinum, lymph nodes	LC-B, NOS	NRc	--	--	A
20	III	Mediastinum	MLBCL	PR	CR*	--	A
21	IV	Bone, mediastinum, lymph nodes, bone marrow	LC-B, NOS	PR	CR*	Mediastinum, bone, bone marrow	D
22	III	Lymph node, bone, soft tissue	DLBCL	CR*	--	--	A
23	III	Mediastinum, lymph nodes, bones	LC, NOS	CR	--	--	A
24	IVa	Brain	LC, NOS	CR	--	--	A
25	IV	Mediastinum, pericardium, bone marrow	LC, NOS	PR	CR*	--	A

^*NR, no response; PR, partial response; CR, complete response (9 patients in whom diagnostic imaging revealed minimal abnormality of questionable significance at the primary site of disease were categorized provisionally as having a CR); A, alive; D, dead; DLBCL, diffuse large B-cell lymphoma; MLBCL, mediastinal large B-cell lymphoma; ALCL, anaplastic large cell lymphoma; LC-T NOS, T-large cell not otherwise specified; LC-B NOS, B-large cell not otherwise specified (with atypical features); LC NOS, large cell not otherwise specified.

^aIncomplete resection (microscopic residual).

^bEmergency mediastinal irradiation at diagnosis.

^cTreatment failure (NR or PR with progressive disease); patient taken off study