Table 3.
No. | Disease Stage | Sites of Disease | Pathology | Response |
|||
---|---|---|---|---|---|---|---|
DAC | DAC + CHOD | Relapse | Status | ||||
1 | III | Bones, soft tissue | DLBCL | CR* | -- | -- | A |
2 | III | Lymph nodes | DLBCL | CR | -- | -- | A |
3 | III | Mediastinum, lung | MLBCL | PR | PR | Mediastinum | A |
4 | IIIa | Intestine | DLBCL | CR | -- | -- | A |
5 | III | Mediastinum, lymph nodes | LC-T,NOS | PRb | PRc | -- | D |
6 | III | Mediastinum, bone, pancreas | LC-T,NOS | CR | -- | -- | A |
7 | III | Skin, lymph nodes, bone | ALCL | PRc | -- | -- | A |
8 | III | Mediastinum, bones, lymph nodes, soft tissue | ALCL | PR | CR* | Bones, lung | D |
9 | III | Mediastinum, abdominal mass, lymph nodes | ALCL | PR | CR* | -- | A |
10 | III | Paraspinal mass, bones | ALCL | PR | PRc | -- | D |
11 | III | Mediastinum, soft tissue, bone | ALCL | NRc | -- | -- | D |
12 | III | Lymph nodes, pleural mass | ALCL | NR(mixed)c | -- | -- | A |
13 | III | Lung, lymph nodes, skin, bones | ALCL | CR | -- | -- | A |
14 | IV | Lymph nodes, bone, spleen, bone marrow | ALCL | CR* | -- | -- | A |
15 | III | Lymph nodes, spleen | ALCL | CR* | -- | -- | A |
16 | III | Lymph nodes, spleen | ALCL | CR | -- | -- | A |
17 | III | Lymph nodes | ALCL | CR | -- | -- | A |
18 | III | Bones, mediastinum, skin, lymph nodes, kidney | ALCL | CR | -- | Skin, lymph node | D |
19 | III | Mediastinum, lymph nodes | LC-B, NOS | NRc | -- | -- | A |
20 | III | Mediastinum | MLBCL | PR | CR* | -- | A |
21 | IV | Bone, mediastinum, lymph nodes, bone marrow | LC-B, NOS | PR | CR* | Mediastinum, bone, bone marrow | D |
22 | III | Lymph node, bone, soft tissue | DLBCL | CR* | -- | -- | A |
23 | III | Mediastinum, lymph nodes, bones | LC, NOS | CR | -- | -- | A |
24 | IVa | Brain | LC, NOS | CR | -- | -- | A |
25 | IV | Mediastinum, pericardium, bone marrow | LC, NOS | PR | CR* | -- | A |
NR, no response; PR, partial response; CR, complete response (9 patients in whom diagnostic imaging revealed minimal abnormality of questionable significance at the primary site of disease were categorized provisionally as having a CR); A, alive; D, dead; DLBCL, diffuse large B-cell lymphoma; MLBCL, mediastinal large B-cell lymphoma; ALCL, anaplastic large cell lymphoma; LC-T NOS, T-large cell not otherwise specified; LC-B NOS, B-large cell not otherwise specified (with atypical features); LC NOS, large cell not otherwise specified.
Incomplete resection (microscopic residual).
Emergency mediastinal irradiation at diagnosis.
Treatment failure (NR or PR with progressive disease); patient taken off study