Table 2.
TGFβ signaling superfamily.
| Type II Rreceptor | Type 1 receptor | Ligands | R-SMAD |
|---|---|---|---|
| TGFβRII | TGFβRI/ALK5 | TGFβ1 | SMAD1.5.8 |
| AcvrL1/ALK1 | TGFβ2 | or | |
| Acvr1/ALK2 | TGFβ3 | SMAD2,3 | |
| ACTIVIN-βA | |||
| Acvr2a | Acvr1b/ALK4 | ACTIVIN-βA,B,C,E | SMAD2.3 |
| Acvr1c/ALK7 | BMP2 | or | |
| BMPRIB/ALK6 | BMP6 | SMAD1,5,8 | |
| BMPRIA/ALK3 | BMP7 | ||
| GDF5 | |||
| GDF8 | |||
| GDF9 | |||
| GDF11 | |||
| NODAL | |||
| Acvr2b | Acvr1/ALK2 | ACTIVIN-βA.B,C,E | SMAD2,3 |
| Acvr1b/ALK4 | NODAL | ||
| Acvr1c/ALK7 | BMP2 | ||
| BMP6 | |||
| BMP7 | |||
| BMPRII | Acvr1/ALK2 | BMP2 | SMAD1,5,8 |
| BMPRIA/ALK3 | BMP4 | ||
| BMPRIB/ALKE | BMP6 | ||
| BMP7 | |||
| GDF5 | |||
| GDF6 | |||
| GDF9 | |||
| AMHR | Acvr1/ALK2 | MIS | SMAD1,5,8 |
| BMPRIA/ALK3 | |||
| BMPRIB/ALKB |
Type II Receptors: There are five Type II receptors; Transforming growth factor beta receptor (TGFbRII), Activin receptor A (Acvr2a), Activin receptor B (Acvr2b), Bone morphogenic protein receptor (BMPRII) and Anti-Mullerian hormone receptor (AMHR). Type I receptors are also called the Activin-like kinases (ALKs) and listed according to known dimerizations with type II receptors. Ligands that correspond to Type I and Type II receptor dimer binding are listed, however, not all of the TGFβ ligands are listed. Mullerian inhibitory substance (MlS), growth differentiation factor (GDF). SMAD signaling pathway associated with each receptor/ligand interaction is shown. Some receptor dimers can signal through either SMAD pathway depending on the activating ligand.