Table 2.

Liver and renal function with tacrolimus dose and concentration

Before pregnancy			First trimester			Second trimester			Third trimester			After delivery
Liver function (mean values)
Bilirubin	AST	ALT	Bilirubin	AST	ALT	Bilirubin	AST	ALT	Bilirubin	AST	ALT	Bilirubin	AST	ALT
0.6	35.3	38.0	0.6	31.5	32.0	0.6	37.0	38.7	0.5	36.7	31.2	0.7	48.7	41.6
0.4	21.1	25.1	0.4	19.6	23.5	0.4	40.3	33.6	0.4	47.0	25.7	0.5	70.6	53.3
0.6	27.5	32.0	0.5	26.5	28.0	0.5	27.0	24.0	0.4	27.0	23.5	0.7	28.0	25.0
Renal function (mean value)
Creatinine	BUN	Creatinine	BUN	Creatinine	BUN	Creatinine	BUN	Creatinine	BUN
1.2	20.3	1.0	17.0	1.0	15.0	1.1	14.2	1.2	18.8
0.5	7.5	0.4	6.6	0.4	6.4	0.4	8.1	0.5	10.2
1.1	18.5	0.9	17.0	0.9	14.0	0.9	13.0	1.1	15.0
Mean tacrolimus—dose mg/day and whole-blood trough concentration ng/mL
Dose	Level	Dose	Level	Dose	Level	Dose	Level	Dose	Level
9.8	7.0	9.5	7.0	9.6	4.5	9.5	4.5	10.9	5.7

Bilirubin mg/dL (1 mg/dL=17 μmol/L, SI units), creatinine mg/dL (1 mg/dL=88.4 μmol/L-SI units).

BUN, blood urea nitrogen-mg/dL (1 mg/dL=0.357 μmol/L SI units); AST, aspartate amino transferase U/L; ALT, alanine amino transferase U/L.