Table 1.

		MS cases with and without Optic Neuritis (ON)				MS cases with Optic Neuritis (ON)
	No	age (years) [range]	disease duration (months) [range]	all Relapses	No	age (years) [range]	disease duration (months) [range]	all Relapses	all ON
Controls	59	38.9±1.35[21 to 67.0]	-	-	-	-	-	-	-
RRMS & SPMS, total	59	39±1.4[19.8 to 68.0]	121.1±14.2	4.5±0.4[1 to 19]	24	40.7±2.4[19.8 to 68.0]	161.4±21.1[25.0 to 350.0]	4.5±0.4[1 to 19]	1.8±0.2[1 to 4]
RRMS, total	42	37.6±1.7[19.8 to 68.0]	90.3±15.2[9.0 to 540.0]	3.8±0.3[1 to 10]	13	38.8±3.8[19.8 to 68.0]	117.3±21.9[25.0 to 324.0]	4.6±0.6[2 to 9]	2.0±0.3[1 to 4]
RRMS, female	31	37.1±2.2[19.8 to 68.0]	101.2±18.8[14.0 to 540.0]	4.1±0.4[2 to 9]	12	38.9±3.8[19.8 to 68.0]	117.3±21.9[25.0 to 324.0]	4.6±0.6[2 to 9]	2.1±0.3[1 to 4]
RRMS, male	11	38.3±2.3[25.0 to 52.0]	56.6±22.4[9.0 to 240.0]	3.0±0.7[1 to 10]	1	33	25	2	1
SPMS, total	17	43.0±2.2[26.0 to 56.0]	197.2±23.8[40.0 to 350.0],	3.3±1.0[1 to 19]	11	42.9±2.8[26.0 to 53.5]	213.5±32.3[40.0 to 350.0]	5.8±0.8[3 to 12]	1.5±0.2[1 to 2]
SPMS, female	10	45.0±2.8[27.0 to 56.0]	210.4±34.2[40.0 to 350.0],	3.0±0.7[1 to 10]	6	46.6±2.7[35.8 to 53.5]	236.8±50.8[40.0 to 350.0]	5.8±1.3[3 to 12]	1.7±0.2[1 to 2]
SPMS, male	7	40.9±3.7[26.0 to 52.0]	148.4±32.7[78.0 to 282.0]	6.5±1.6[3 to 19]	5	38.5±4.9[26.0 to 52.0]	102.±38.9[102.0 to 282.0]	5.8±1.2[3 to 10]	1.4±0.2[1 to 2]