Table 1.
Percent identity (%) of nucleotide and amino acid sequences in different gene fragment between subgenogroup C2-like and other subgenogroups of enterovirus 71*
| Sub- genogroup | Gene | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5'-UTR | VP4 | VP2 | VP3 | VP1 | 2A | 2B | 2C | 3A | 3B | 3C | 3D | Complete | ||
| A | nt | 83.1 | 84.0 | 80.8-81.1 | 83.0-83.3 | 83.8 | 79.1 | 76.0 | 78.3 | 77.9-78.2 | 72.7 | 76.5 | 76.8 | 79.3-79.4 |
| aa | 100 | 97.6 | 97.9 | 94.9 | 96.6 | 92.9 | 96.6 | 97.6 | 90.9 | 93.4 | 91.7 | 95.3 | ||
| B1 | nt | 84.2-84.4 | 78.7 | 84.5-84.6 | 79.6-79.8 | 83.5-83.7 | 76.8-78.0 | 72.3-73.0 | 82.4-82.5 | 81.3-81.7 | 81.8 | 79.5-80.5 | 77.7-78.3 | 80.2-80.6 |
| aa | 98.5-100 | 97.6 | 97.5 | 96.9-97.3 | 94.0-94.6 | 91.9-92.9 | 95.1-95.4 | 96.5 | 95.4 | 96.7 | 93.2-94.3 | 95.8-95.9 | ||
| B2 | nt | 85.1-85.2 | 80.1 | 84.1 | 80.3-80.5 | 83.3-83.6 | 79.1 | 73.4 | 82.6 | 78.6-79.0 | 80.3 | 78.5 | 78.3-78.4 | 80.3-80.5 |
| aa | 100 | 97.6 | 97.1 | 97.3 | 94.6 | 92.9 | 94.5 | 97.6 | 95.4 | 96.7 | 93.9-94.1 | 95.8 | ||
| B3 | nt | 84.1-84.6 | 82.6-83.0 | 82.4-82.5 | 79.2-79.6 | 82.9-83.3 | 78.8-79.1 | 76.7 | 83.4-83.6 | 83.7-84.4 | 90.9 | 85.4-85.6 | 84.7-85.2 | 82.4-82.6 |
| aa | 100 | 97.6-98.0 | 96.6 | 96.9 | 95.3 | 94.9 | 97.5-97.8 | 98.8 | 95.4 | 98.3 | 96.5-97.4 | 97.0-97.3 | ||
| B4 | nt | 83.9-84.5 | 83.0 | 83.3-83.4 | 80.3-80.4 | 83.3-83.6 | 80.6 | 75.0 | 82.3-82.6 | 79.0-79.8 | 83.3 | 78.6-78.8 | 78.2-78.5 | 80.4-80.6 |
| aa | 100 | 98.0 | 97.1 | 97.6 | 95.3 | 92.9 | 96.3 | 95.3-96.5 | 100 | 95.6 | 94.5-94.8 | 96.2-96.3 | ||
| B5 | nt | 79.8-83.4 | 82.6-83.5 | 81.7-82.8 | 80.9-82.3 | 83.6-84.5 | 80.6-81.7 | 73.0-73.7 | 82.1-82.8 | 79.4-81.0 | 84.8-86.3 | 77.7-78.1 | 77.5-78.1 | 80.3-80.5 |
| aa | 100 | 97.2-98.0 | 97.1 | 97.9-98.3 | 94.0-95.4 | 92.9 | 95.7-96.3 | 97.6 | 95.4-100 | 95.0-96.1 | 94.1-94.5 | 96.1-96.3 | ||
| C1 | nt | 81.6-82.2 | 88.4 | 88.5-88.9 | 88.2-89.6 | 88.4-89.0 | 85.5-86.2 | 84.8-85.1 | 79.7-79.9 | 75.9-77.1 | 77.2-78.7 | 75.2-75.5 | 79.4-79.9 | 82.4-83.0 |
| aa | 98.5-100 | 99.2-99.6 | 99.1-99.5 | 99.6 | 96.6-97.3 | 94.9 | 96.6-96.9 | 91.8 | 95.4 | 93.4-93.9 | 94.3-94.5 | 96.7-96.9 | ||
| C2 | nt | 81.2-83.3 | 91.7-94.6 | 93.7-94.4 | 93.8-95.1 | 91.9-93.0 | 90.8-92.6 | 90.9-91.5 | 78.7-80.4 | 77.1-79.0 | 75.7-77.2 | 73.2-75.0 | 78.9-80.0 | 84.0-85.4 |
| aa | 100 | 99.2-100 | 100 | 98.6-99.6 | 98.6 | 91.9-93.9 | 91.1-96.9 | 87.2-93.0 | 95.4 | 87.4-93.9 | 93.2-94.3 | 95.1-96.9 | ||
| C3 | nt | 83.2-83.5 | 87.9 | 90.4-90.5 | 90.4-91.0 | 88.1-88.6 | 86.8-87.1 | 88.5 | 78.8-79.0 | 77.1-77.9 | 75.7 | 75.4-75.7 | 78.5-78.9 | 82.9-83.2 |
| aa | 100 | 99.6 | 100 | 99.6 | 96.6-97.3 | 93.9 | 97.2 | 93.0 | 95.4 | 92.3-92.8 | 93.9-94.1 | 96.8 | ||
| C4 | nt | 83.1-84.1 | 88.4-90.8 | 88.7-90.6 | 89.2-90.4 | 86.1-87.9 | 82.6-84.0 | 73.7-75.4 | 82.4-83.5 | 80.2-81.3 | 83.3-86.3 | 83.0-83.7 | 81.8-83.6 | 83.8-84.4 |
| aa | 97.1-100 | 99.6-100 | 98.7-99.5 | 98.6-99.6 | 95.3-96.0 | 92.9-94.9 | 97.2-98.4 | 97.6-98.8 | 95.4 | 96.1-97.2 | 95.4-96.5 | 97.4-97.9 | ||
| C5 | nt | 82.5-82.9 | 89.3-90.3 | 88.0-88.7 | 87.1-87.4 | 87.8 | 86.2-86.8 | 82.4-83.1 | 78.3-79.3 | 74.0-74.8 | 80.3-81.8 | 76.3-76.5 | 77.3-77.4 | 81.4-82.5 |
| aa | 100 | 99.6 | 100 | 98.6-99.6 | 96.0 | 91.9-93.9 | 97.2 | 93.0-94.1 | 95.4 | 93.4-93.9 | 93.2-93.9 | 96.6-96.7 | ||
*Subgenogroup A: BrCr-CA-70 (GenBank accession no. U22521), B1: 236-TW86 (FJ357379) and 244-TW86 (FJ357381), B2: 26M/AUS/4/99 (EU364841), B3: SAR/SHA66 (AM396586) and 26M/AUS/4/99 (EU364841), B4: 5865/SIN/000009 (AF316321) and 5666/SIN/002209 (AF352027), B5: S19841-SAR-03 (DQ341363), 2007-08747 (EU527985) and 2009-03531 (HM622390), C1: 804/NO/03 (DQ452074) and 1M-AUS-12-00 (DQ341361), C2: 1245a/98/TW (AF176044), ENT/PM/SHA71 (AM396585), Tainan/5746/98 (AF304457), TW/2086/98 (AF119796) and 6F/AUS/6/99 (DQ381846), C3: 06/KOR/00 (DQ341355) and 03/KOR/00 (DQ341355), C4: 1235/04/TW (DQ133459), BJ08/Z004/3 (FJ606447), 1/SHENZHEN/08 (FJ607334), Shanghai/036/2009 (FJ713137) and SHZH03-CHN (AY465356), C5: E2005125-TW (EF063152) and 2007-07364 (EU527983), C2-like: 2008-00643 (HM622391) and 2008-07776 (HM622392).