Table 1.

Potential mechanisms of ONJ [19]

Inhibition of bone remodeling	Compromised bone microenvironment functioning affecting bone remodeling and repair
Vascular	Antiangiogenic affects delaying wound healing and/or affecting micro-infarction in bone and/or soft tissues
Infection and inflammation	Microorganisms of the oral cavity promoting cell death in the bone and/or oral soft tissues
Genetic predisposition	Genetic polymorphisms affecting drug metabolism, excretion, or drug targets within pathways of bone metabolism and/or wound healing
Drug interactions	Drug interactions between chemotherapy and bisphosphonate selectively promoting cell death