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. 2010 Nov 8;5(11):e15476. doi: 10.1371/journal.pone.0015476

Figure 2. Prototype assay for 17 drug resistance mutations in HIV-1 Pol.

Figure 2

(A) Schematic representation of HIV-1 pol gene and relative locations of drug resistance-associated codons in HIV-1 protease (PR), reverse transcriptase (RT) and integrase (IN) coding regions. (B) Correct signal from the prototype assay are shown with amplitude in units of median fluorescence intensity (MFI; calculated for ≥75 beads per well; +/−s.d., N = 3 independent experiments). (C) Incorrect signal amplitude in the prototype assay (+/−s.d., N = 3 independent experiments). *Multiple incorrect signals were averaged for PR-084 and IN-148 detections.