Figure 1.

A schematic representation of Notch, SMRT and KyoT2. The GST fusion proteins and the activators used in this study are displayed. Vertically hatched, diagonally hatched, dotted, horizontally hatched, and checkered boxes indicate the transmembrane (TM), RAM, ANK (CDC10/ankyrin repeats) and PEST regions of Notch, and the CID region (CBF1/RBP-J interaction domain) of SMRT, respectively. The diagonally hatched circle and black ellipses indicate the OPA and nuclear localization signals (NLS), respectively. The numbers represent the amino acid positions of their ends.