Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2010 Nov 8.

Published in final edited form as: Cancer Gene Ther. 2007 Dec 14;15(2):115–125. doi: 10.1038/sj.cgt.7701110

(a). Human primary ovarian tumor cells (HGOP-1680 and TPO2-738R) were compared with a human ovarian tumor cell line (A2780) following infection with increasing doses of vvDD-CD. The cell viability at 48 h post infection was determined by MTS assays. (b). MOSEC murine ovarian cancer cells were treated with vvDD-CD and vvDD at MOI = 0.1 in the absence of 5-FC and cell viability was measured with a MTS assay. The data showed infected cell viability was time-dependent. (c). A viral dose- and time-dependent cytotoxicity by vvDD-CD on MOSEC cells. (d). Synergistic cytotoxic effect of vvDD-CD and 5-FC on MOSEC cancer cells. MOSEC cells treated with none, 5-FC (0.5 mM), vvDD-CD (MOI = 0.1) or the dual treatment over time. Combination treatment showed increased cytotoxicity compared to vvDD-CD alone. The values are the mean +/−SEM. Data are representative of three independent experiments. (* p<0.01, ** p<0.02, *** p<0.04, **** p<0.05)

(a). Human primary ovarian tumor cells (HGOP-1680 and TPO2-738R) were compared with a human ovarian tumor cell line (A2780) following infection with increasing doses of vvDD-CD. The cell viability at 48 h post infection was determined by MTS assays. (b). MOSEC murine ovarian cancer cells were treated with vvDD-CD and vvDD at MOI = 0.1 in the absence of 5-FC and cell viability was measured with a MTS assay. The data showed infected cell viability was time-dependent. (c). A viral dose- and time-dependent cytotoxicity by vvDD-CD on MOSEC cells. (d). Synergistic cytotoxic effect of vvDD-CD and 5-FC on MOSEC cancer cells. MOSEC cells treated with none, 5-FC (0.5 mM), vvDD-CD (MOI = 0.1) or the dual treatment over time. Combination treatment showed increased cytotoxicity compared to vvDD-CD alone. The values are the mean +/−SEM. Data are representative of three independent experiments. (* p<0.01, ** p<0.02, *** p<0.04, **** p<0.05)