Fig. 3.
Effects of rHDL on vascular remodeling and carotid atherosclerosis in apoE−/− mice. A: Representative hematoxylin and eosin staining of collared right carotid arteries at 20× magnification after injection with (a) saline (n = 5); (b) SPC (n = 5); (c) rHDLwt (n = 6); (d) rHDL74 (n = 6); and (e) rHDLmilano (n = 6). Sham-operated left carotid arteries from saline group did not show neointima formation (f) at 10× magnification. B-D: Quantitative analysis of the extent of atheroma, intima/media ratio, and lipid content in neointima. Results are expressed as mean ± SD. ★P < 0.05 compared with saline group; †P < 0.05 compared with SPC group; §P < 0.05 compared with rHDLwt group. rHDL, recombinant HDL; L, lumen; SPC, soybean lecithin.