TABLE 2.
Fecal neutral sterols and bile acids in hamster RCT study
| Control | Dalcetrapib | Torcetrapib | Anacetrapib | |
|---|---|---|---|---|
| 100 mg/kg BID | 30 mg/kg QD | 30 mg/kg QD | ||
| Neutral sterols (mg/total feces) | 40.4 ± 1.1 | 38.7 ± 3.0 | 41.2 ± 2.3 | 40.9 ± 2.8 |
| Bile acids (µmol/total feces) | 67.0 ± 6.6 | 86.0 ± 6.0b | 74.6 ± 5.6 | 69.8 ± 7.2 |
| Total radioactivity (% of injected) | 13.3 ± 1.3 | 17.5 ± 0.5c | 16.5 ± 0.5c | 13.2 ± 1.5 |
| [3H]neutral sterols (% of injected) | 3.0 ± 0.3 | 3.6 ± 0.3b | 3.3 ± 0.3 | 3.0 ± 0.3 |
| [3H]bile acids (% of injected) | 6.9 ± 0.8 | 8.8 ± 0.7b | 8.2 ± 0.3a | 6.7 ± 0.7 |
| [3H]total sterols (% of injected) | 9.9 ± 0.9 | 12.5 ± 0.5b | 11.5 ± 0.5b | 9.7 ± 0.9 |
Feces were collected for 10 days after injection of [3H]cholesterol-labeled macrophages. Total radioactivity is the count of whole fecal homogenates. [3H]total sterols is the sum of [3H]neutral sterols and [3H]bile acids. The data are presented as mean ± SD, n = 5–6. RCT, reverse cholesterol transport.
a
P < 0.05.
b
P < 0.01 vs. control (Dunnett test).
c
P < 0.05 vs. control (Steel test).