Table 1.
Subject characteristics
| a Characteristics of the primary care (Kaiser) population | |||
|---|---|---|---|
| Lower BP | Higher BP | All | |
| Male/female, n | 251/349 | 265/287 | 516/636 |
| Age, years | 56.7 ± 0.6 | 59.9 ± 0.4 | 58.3 ± 0.4 |
| SBP, mm Hg | 107.8 ± 0.6 | 154.5 ± 0.6 | 129.9 ± 0.8 |
| DBP, mm Hg | 56.3 ± 0.1 | 99.2 ± 0.2 | 76.9 ± 0.6 |
| GFR, ml/min/1.73 m2 | 74.3 ± 0.6 | 74.1 ± 0.7 | 74.1 ± 0.5 |
| Biogeographic ancestry | all white/European | ||
| b Characteristics of the primary care (VA) hypertension population | ||
|---|---|---|
| GFR ml/min/1.73 m2 | ||
| Demographic | ||
| Male/female, n | 530/17(96.996/3.1%) | |
| Biogeographic ancestry | all white/European | |
| Age, years | 66.3 ± 0.5 | |
| SBP, mm Hg | 140.1 ± 0.8 | |
| DBP, mm Hg | 75.4 ± 0.5 | |
| GFR, ml/min/1.73 m2 | 71.8 ± 1.0 | |
| Antihypertensive drugs, % on each class at entry | ||
| ACEI | 54.7 | 74.5 ± 1.1 |
| ARB | 7.3 | 73.7 ± 3.1 |
| α1-Antagonist | 18.3 | 72.8 ± 2.0 |
| α2-Agonist | 5.4 | 75.4 ± 3.6 |
| β-Antagonist | 43.5 | 74.2 ± 1.3 |
| Calcium channel antagonist | 30.6 | 72.0 ± 1.5 |
| Diuretic | 46.9 | 74.3 ± 1.2 |
| None | 9.9 | 71.6 ± 2.6 |
| Other(s) | 26.4 | 73.1 ± 1.6 |
| Number of antihypertensive drugs, % at entry | ||
| 0 | 9.9 | 71.6 ± 2.6 |
| 1 | 20.1 | 73.8 ± 1.9 |
| 2 | 27.4 | 74.0 ± 1.6 |
| 3 | 22.2 | 74.8 ± 1.7 |
| 4 | 13.6 | 77.8 ± 2.3 |
| 5 | 5.6 | 66.4 ± 3.4 |
| 6 | 1.2 | 59.4 ± 8.6 |
| 7 | 0.1 | 62.9 ± 24.3 |
| c Characteristics of the genotyped hypertensive nephrosclerosis (NIDDK AASK) cohort | |
|---|---|
| Demographic | |
| Male/female, n | 466/310 |
| Biogeographic ancestry | all African-American |
| Age, years | 66.6 ± 0.4 |
| Blood pressure goal, usual/low | 391/385 |
| Antihypertensive drugs, randomized to: ramipril/metoprolol/amlodipine | 325/304/147 |
| Physiological | |
| Baseline GFR, ml/min/1.73 m2 | 46.7 ± 0.5 |
| Urine protein/creatinine, g/g | 0.29 ± 0.17 |
| GFR slope, ml/min/1.73 m2/year | −1.93 ± 0.83 |
Because of multiple medications in some individuals, the total equals >100% in Antihypertensive drugs'. Since each individual was tallied once, the total equals 100% in 'Number of antihypertensive drugs'.