Table 4.
KCNMB1 Glu65Lys (E65K) effects on GFR in primary care populations: eGFR calculated by the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) algorithm
| Population |
||
|---|---|---|
| Kaiser | VA | |
| Biogeographic ancestry | white | white |
| Source | primary care | primary care |
| Dependent variable | GFR (CKD-EPI) | GFR (CKD-EPI) |
| One-way AN OVA | ||
| Overall | p < 0.001 | p < 0.001 |
| Gene | p = 0.046 | p = 0.020 |
| Covariates | ||
| BP status | p = 0.054 | all with hypertension |
| Age | p < 0.001 | p < 0.001 |
| Drug | p = 0.056 | p = 0.382 |
| Sex | p = 0.221 | p = 0.890 |
| GFR, ml/min/1.73 m2 | ||
| KCNMB1: E/E | 74.8 ± 0.4 (n = 971) | 66.9 ± 0.9 (n = 479) |
| KCNMB1: E/K+K/K | 77.0 ± 1.0 (n= 181) | 73.1 ± 2.4 (n = 68) |
Values in italics indicate sigificance.