Fig. 2.

A_2AR KO mice exhibited elevation in RVSP and hypertrophy of RV. RVSP and hypertrophy measurements were made in adult A_2AR KO and WT littermates as described in Materials and Methods. a Representative pictures of RVSP waves in WT and A_2AR KO mice. b Mean RVSP (mm Hg) in WT (n = 5) and A_2AR KO (n = 7) mice. ∗∗ p < 0.01, A_2AR KO vs. WT, one-way ANOVA, Dunnett's post hoc test. c Fulton index in WT and A_2AR KO mice. WT, n = 16; A_2AR KO, n = 18. ∗ p < 0.05, A_2AR KO vs. WT, one-way ANOVA, LSD test.