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A2AR KO mice exhibited hypertrophy of pulmonary resistance vessels with increased wall thickness and area. Pulmonary vascular wall thickness and wall areas in A2AR KO mice and WT littermates were assessed as described in Materials and Methods. a Representative photomicrograph of pulmonary vascular remodeling in lung. ×200. b Percentage of wall thickness. c Wall areas in WT and A2AR KO mice. ∗ p < 0.05, A2AR KO vs. WT, one-way ANOVA, LSD test, n = 9.
