Fig. 6.
A2AR KO mice exhibited increased activation and proliferation of endothelium cells and smooth muscle as well as enhanced hyperplasis of fibroblasts of pulmonary arteries at ultrastructure level. Transmission electron micrographs of mouse pulmonary arteries: endothelial cell in pulmonary artery endomembrane layer (a), SMC in pulmonary artery tunica media layer (b) and collagen in pulmonary artery wall (c). Red arrow = cells in pulmonary artery (color only in online version); blue arrow = deposited collagen fibers; yellow arrow = Weibel-Palade bodies in endothelial cell. a ×12,000. b, c ×10,000.