Table 3.
Analysis of BANK1 polymorphisms according to systemic sclerosis (SSc)-specific autoantibodies
| Population | GG | GA | AA | Allele G | Allele A | p Value G allele | OR (95% CI) | |
|---|---|---|---|---|---|---|---|---|
| rs10516487 | ||||||||
| USA | ACA (n = 298) | 0.48 | 0.41 | 0.11 | 0.68 | 0.32 | 0.85 | 1.02 (0.83 to 1.25) |
| ATA (n = 173) | 0.50 | 0.41 | 0.09 | 0.71 | 0.29 | 0.29 | 1.14 (0.88 to 1.48) | |
| Controls (n = 694) | 0.46 | 0.44 | 0.10 | 0.68 | 0.32 | |||
| Spanish | ACA (n = 155) | 0.46 | 0.45 | 0.09 | 0.69 | 0.31 | 0.18 | 0.84 (0.65 to 1.08) |
| ATA (n = 68) | 0.59 | 0.34 | 0.07 | 0.76 | 0.24 | 0.39 | 1.17 (0.78 to 1.75) | |
| Controls (n = 1040) | 0.52 | 0.40 | 0.08 | 0.72 | 0.28 | |||
| Dutch | ACA (n = 37) | 0.50 | 0.42 | 0.07 | 0.71 | 0.29 | 0.85 | 1.03 (0.72 to 1.46) |
| ATA (n = 28) | 0.54 | 0.39 | 0.07 | 0.73 | 0.27 | 0.70 | 1.09 (0.59 to 2.01) | |
| Controls (n = 255) | 0.49 | 0.44 | 0.07 | 0.71 | 0.29 | |||
| Swedish | ACA (n = 16) | 0.56 | 0.38 | 0.06 | 0.75 | 0.25 | 0.54 | 1.20 (0.54 to 2.64) |
| ATA (n = 11) | 0.64 | 0.27 | 0.09 | 0.77 | 0.23 | 0.46 | 1.29 (0.49 to 3.40) | |
| Controls (n = 565) | 0.49 | 0.42 | 0.09 | 0.70 | 0.30 | |||
| German | ACA (n = 66) | 0.50 | 0.44 | 0.06 | 0.72 | 0.28 | 0.46 | 1.15 (0.76 to 1.73) |
| ATA (n = 41) | 0.51 | 0.41 | 0.07 | 0.72 | 0.28 | 0.55 | 1.14 (0.69 to 1.88) | |
| Controls (n = 360) | 0.46 | 0.55 | 0.09 | 0.69 | 0.31 | |||
| Italian | ACA (n = 107) | 0.50 | 0.42 | 0.07 | 0.71 | 0.29 | 0.63 | 1.08 (0.77 to 1.51) |
| ATA (n = 114) | 0.59 | 0.33 | 0.08 | 0.75 | 0.25 | 0.10 | 1.32 (0.94 to 1.86) | |
| Controls (n = 334) | 0.49 | 0.41 | 0.10 | 0.70 | 0.30 | |||
| Pooled* | ACA (n = 749) | 0.49 | 0.42 | 0.09 | 0.70 | 0.30 | 0.97 | 1.00 (0.88 to 1.40) |
| ATA (n = 435) | 0.54 | 0.37 | 0.08 | 0.73 | 0.27 | 0.03 | 1.20 (1.02 to 1.41) | |
| Controls (n = 3284) | 0.49 | 0.42 | 0.09 | 0.70 | 0.30 | |||
| TT | CT | CC | Allele T | Allele C | p Value T allele | |||
| rs17266594 | ||||||||
| USA | ACA (n = 294) | 0.47 | 0.41 | 0.11 | 0.68 | 0.32 | 0.81 | 1.02 (0.83 to 1.26) |
| ATA (n = 173) | 0.50 | 0.41 | 0.09 | 0.71 | 0.29 | 0.235 | 1.16 (0.90 to 1.50) | |
| Controls (n = 695) | 0.45 | 0.44 | 0.11 | 0.67 | 0.33 | |||
| Spanish | ACA (n = 161) | 0.48 | 0.11 | 0.11 | 0.69 | 0.31 | 0.17 | 0.83 (0.64 to 1.07) |
| ATA (n = 72) | 0.57 | 0.41 | 0.08 | 0.74 | 0.26 | 0.67 | 1.07 (0.73 to 1.57) | |
| Controls (n = 1048) | 0.52 | 0.42 | 0.06 | 0.73 | 0.27 | |||
| Dutch | ACA (n = 37) | 0.54 | 0.41 | 0.05 | 0.74 | 0.26 | 0.54 | 1.15 (0.67 to 2.00) |
| ATA (n = 28) | 0.54 | 0.39 | 0.07 | 0.73 | 0.27 | 0.72 | 1.08 (0.59 to 2.00) | |
| Controls (n = 256) | 0.48 | 0.45 | 0.07 | 0.71 | 0.29 | |||
| Swedish | ACA (n = 16) | 0.56 | 0.38 | 0.06 | 0.75 | 0.25 | 0.54 | 1.20 (0.54 to 2.64) |
| ATA (n = 11) | 0.64 | 0.27 | 0.09 | 0.77 | 0.23 | 0.46 | 1.29 (0.49 to 3.40) | |
| Controls (n = 565) | 0.49 | 0.42 | 0.09 | 0.70 | 0.30 | |||
| German | ACA (n = 66) | 0.50 | 0.44 | 0.06 | 0.72 | 0.28 | 0.46 | 1.15 (0.76 to 1.73) |
| ATA (n = 41) | 0.51 | 0.42 | 0.07 | 0.72 | 0.28 | 0.55 | 1.14 (0.69 to 1.88) | |
| Controls (n = 360) | 0.46 | 0.45 | 0.09 | 0.69 | 0.31 | |||
| Italian | ACA (n = 107) | 0.51 | 0.40 | 0.08 | 0.72 | 0.29 | 0.161 | 1.27 (0.90 to 1.78) |
| ATA (n = 112) | 0.59 | 0.34 | 0.07 | 0.76 | 0.24 | 0.01 | 1.59 (1.12 to 2.24) | |
| Controls (n = 307) | 0.43 | 0.47 | 0.10 | 0.66 | 0.34 | |||
| Pooled* | ACA (n = 632) | 0.53 | 0.37 | 0.10 | 0.70 | 0.30 | 0.61 | 1.03 (0.91 to 1.18) |
| ATA (n = 478) | 0.50 | 0.43 | 0.07 | 0.73 | 0.27 | 0.01 | 1.24 (1.05 to 1.46) | |
| Controls (n = 3231) | 0.48 | 0.43 | 0.08 | 0.70 | 0.30 | |||
| GG | GA | AA | Allele G | Allele A | p Value G allele | |||
| rs3733197 | ||||||||
| USA | ACA (n = 299) | 0.41 | 0.44 | 0.15 | 0.63 | 0.37 | 0.85 | 1.02 (0.84 to 1.24) |
| ATA (n = 173) | 0.50 | 0.42 | 0.08 | 0.71 | 0.29 | 0.004 | 1.45 (1.13 to 1.88) | |
| Controls (n = 696) | 0.39 | 0.47 | 0.14 | 0.62 | 0.38 | |||
| Spanish | ACA (n = 164) | 0.43 | 0.48 | 0.09 | 0.67 | 0.33 | 0.29 | 0.87 (0.68 to 1.12) |
| ATA (n = 72) | 0.44 | 0.46 | 0.10 | 0.67 | 0.33 | 0.56 | 0.89 (0.62 to 1.28) | |
| Controls (n = 1051) | 0.49 | 0.42 | 0.10 | 0.70 | 0.30 | |||
| Dutch | ACA (n = 28) | 0.39 | 0.54 | 0.07 | 0.66 | 0.34 | 0.69 | 1.10 (0.62 to 1.96) |
| ATA (n = 37) | 0.51 | 0.30 | 0.19 | 0.66 | 0.34 | 0.64 | 1.11 (0.67 to 1.86) | |
| Controls (n = 250) | 0.40 | 0.48 | 0.13 | 0.63 | 0.37 | |||
| Swedish | ACA (n = 16) | 0.38 | 0.50 | 0.13 | 0.63 | 0.38 | 0.91 | 1.01 (0.49 to 2.07) |
| ATA (n = 11) | 0.46 | 0.46 | 0.09 | 0.68 | 0.32 | 0.52 | 1.25 (0.52 to 3.03) | |
| Controls (n = 444) | 0.37 | 0.50 | 0.14 | 0.62 | 0.39 | |||
| German | ACA (n = 76) | 0.49 | 0.43 | 0.08 | 0.70 | 0.30 | 0.05 | 1.44 (0.99 to 2.10) |
| ATA (n = 42) | 0.45 | 0.45 | 0.10 | 0.68 | 0.32 | 0.29 | 1.27 (0.79 to 2.05) | |
| Controls (n = 362) | 0.41 | 0.42 | 0.17 | 0.62 | 0.38 | |||
| Italian | ACA (n = 105) | 0.44 | 0.41 | 0.15 | 0.64 | 0.36 | 0.79 | 0.95 (0.69 to 1.32) |
| ATA (n = 112) | 0.51 | 0.40 | 0.09 | 0.71 | 0.29 | 0.12 | 1.29 (0.93 to 1.79) | |
| Controls (n = 340) | 0.41 | 0.49 | 0.10 | 0.65 | 0.35 | |||
| Pooled* | ACA (n = 688) | 0.42 | 0.45 | 0.13 | 0.65 | 0.35 | 0.81 | 1.02 (0.89 to 1.15) |
| ATA (n = 447) | 0.49 | 0.42 | 0.10 | 0.70 | 0.30 | 0.004 | 1.26 (1.07 to 1.47) | |
| Controls (n = 3143) | 0.42 | 0.45 | 0.12 | 0.65 | 0.35 |
*
Mantel–Haenszel test under fixed effects.
ACA, anticentromere antibodies; ATA, anti-topoisomerase antibodies.