Figure 3.
Effect on Ca2+-sensitivity of skinned cardiac trabeculae by dfbp-o. The relationship between [Ca2+] and relative force at various [Ca2+] was determined in the absence (O) and presence of 500 μM dfbp-o (Δ). In the presence of dfbp-o, the relative force at Ca2+ concentrations of 1.0 μM and 1.5 μM were significantly higher than the control. Mean results were fit to the Hill equation and shown as dashed (control) or solid (dfbp-o) lines. The fine dashed line represents the change in force in the presence of dfbp-o.