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. Author manuscript; available in PMC: 2011 Sep 22.
Published in final edited form as: Biochim Biophys Acta. 2010 Sep 22;1799(9):622–629. doi: 10.1016/j.bbagrm.2010.09.003

Figure 8. Model for Per1 action on αENaC gene expression.

Figure 8

The work described in the present study, together with previous reports on the regulation of αENaC by Per1 [8] and corticosteroids [36] have led to a proposed model for a transcriptional mechanism of gene regulation. A. In the absence of Per1, the Bmal/Clock heterodimer is bound to the promoter and αENaC mRNA levels are low. B. Per1 and its binding partner Cry are present at the promoter via interaction with Bmal/Clock to drive αENaC transcription under basal conditions. C. In the presence of aldosterone (A) the mineralocorticoid receptor (MR) heterodimerizes and translocates to the nucleus to increase transcription of αENaC. When Per1 is present, αENaC transcription is highly induced through the action of Per1 and MR.