Table 2.

Diagnostic yield among 13,115 colposcopically-guided biopsy examinations processed at Alberta Hospital 2003–2007: Percent of exams where endocervical curettage (ECC) detected CIN2^* or worse that would have been missed by cervical biopsy alone (cbiopsy diagnosis less than CIN2), stratified by patient and colposcopy characteristics

	Total			Age 16–45		Age 46–96
	N	Column percent	Percent diagnostic yield	N	Percent diagnostic yield	N	Percent diagnostic yield
TOTAL	13115	100.0	1.0	10567	0.9	2548	1.4
Age at admission (mean=35.6, median=33 years)
17–25	2203	16.8	0.6
26–35	5461	41.6	1.0
36–45	2903	22.1	1.0
46–55	1905	14.5	1.4
56–94	643	4.9	1.2
p-valueα			.023
Method of contraception
None	2216	16.1	1.3	1423	1.2	693	1.4
Pill	4734	36.1	0.7	4543	0.6	191	1.1
Other	4112	31.4	1.2	3028	1.1	1084	1.5
Missing	2153	16.4	1.2	1573	1.2	580	1.2
p-valueβ			.013		.055		.898
Number of live births
0	5909	45.1	0.9	5618	0.8	291	1.4
1–3	4825	36.8	1.1	3219	1.0	1606	1.3
4–11	304	2.3	2.0	157	0.6	147	3.4
Missing	2077	15.8	1.1	1573	1.1	504	1.0
p-valueαβ			.048		.521		.211
Colposcopy exam satisfactory
Yes	8933	68.1	0.8	7512	0.7	1421	1.3
No	1685	12.9	1.5	1152	1.7	533	1.1
Missing	2497	19.0	1.3	1903	1.2	594	1.7
p-valueβ			.005		.001		.711
Colposcopic impression
Normal	724	5.5	0.7	453	0.2	271	1.5
Atypia	1089	8.3	0.7	675	0.9	414	0.5
Low Grade	7590	57.9	0.9	6376	0.8	1214	1.2
High Grade/Cancer	1892	14.4	1.6	1725	1.3	167	4.8
Missing	1820	13.9	1.2	1338	1.2	482	1.2
p-valueαβ			.015		.035		.037
Referral cytology
ASC-US	1471	11.2	0.8	1028	0.9	443	0.5
AGUS	145	1.1	1.4	89	1.1	56	1.8
LSIL	2940	22.4	1.0	2528	1.0	412	1.5
HSIL	2177	16.6	2.4	1873	1.9	304	5.3
Cancer	21	0.2	4.8	15	0.0	6	16.7
Unsatisfactoryγ	15	0.1	0.0	11	0.0	4	0.0
Follow-up visit	6346	48.4	0.6	5023	0.5	1323	0.7
p-valueδ			<.001		.003		<.001

^*Cervical intraepithelial neoplasia grade 2

^αChi-square test for trend

^βMissing values excluded from statistical calculation of significance.

^γNo CIN2+ was detected among women with an unsatisfactory referral cytology.

^δChi-square test for trend excludes unsatisfactory and follow-up test results.