Table 3.

Unadjusted effects of psychosocial and physiologic variables on fatigue intensity and fatigue-related impairment of functioning

Measure	Fatigue intensity				Fatigue-related impairment of functioning
	Effect of within-person …				Effect of within-person…
	Mean		Deviation		Mean		Deviation
	Estimate	P	Estimate	P	Estimate	P	Estimate	P
Psychosocial measures
Number of stressful events	0.439	< 0.001	0.097	0.021	0.414	< 0.001	0.090	0.032
Davidson PTSD score	0.540	< 0.001	0.077	0.156	0.559	< 0.001	0.082	0.124
HADS anxiety score	0.726	< 0.001	0.220	< 0.001	0.688	< 0.001	0.227	< 0.001
Beck Depression Inventory score	0.689	< 0.001	0.222	< 0.001	0.713	< 0.001	0.202	< 0.001
Social support	−0.206	0.018	−0.120	0.163	−0.278	0.001	0.003	0.969
Number of childhood traumasa	0.251	0.001	–	–	0.280	< 0.001	–	–
Physiologic measures
Aspartate aminotranspertase	0.027	0.770	−0.105	0.122	−0.001	0.992	−0.076	0.250
Alanine aminotraspertase	−0.038	0.677	−0.102	0.130	−0.071	0.440	−0.107	0.101
Gamma glutamyl transpeptidaseb	0.008	0.926	−0.189	0.099	0.005	0.954	−0.129	0.258
Alkaline phosphatase	0.136	0.119	−0.130	0.133	0.142	0.105	−0.087	0.303
Total bilirubin	−0.046	0.621	0.005	0.934	−0.005	0.956	0.042	0.465
TSH	−0.042	0.634	−0.153	0.076	−0.032	0.721	−0.008	0.924
Thyroxine	0.003	0.975	0.105	0.173	0.037	0.684	0.083	0.265
HIV RNA viral loadb	0.093	0.342	0.013	0.803	0.058	0.551	−0.035	0.506
CD4 count	−0.130	0.124	−0.100	0.339	−0.070	0.411	0.023	0.827
CD4 percent	−0.150	0.068	−0.140	0.342	−0.108	0.192	−0.033	0.823
CD4/CD8 ratio	−0.151	0.085	−0.116	0.173	−0.122	0.168	−0.020	0.817
T4/T8 ratiob	−0.125	0.151	0.064	0.477	−0.094	0.279	−0.030	0.736
CD16 count	−0.130	0.266	0.018	0.699	−0.020	0.866	0.023	0.623
CD16 percent	−0.054	0.658	0.030	0.530	0.025	0.838	0.024	0.613
CD38 on CD8	0.039	0.660	−0.060	0.399	0.023	0.793	−0.085	0.230
Total testosterone	−0.097	0.245	0.037	0.804	−0.081	0.340	0.155	0.275
Free testosterone	−0.147	0.085	0.034	0.759	−0.072	0.407	0.079	0.459
DHEA	−0.172	0.045	0.122	0.304	−0.144	0.096	0.195	0.086
Hemoglobin	−0.098	0.242	−0.102	0.182	−0.100	0.231	−0.037	0.629
Hematocrit	−0.071	0.408	−0.092	0.196	−0.086	0.314	−0.033	0.640
Serum erythropoietinb	−0.092	0.309	0.053	0.562	−0.037	0.685	−0.016	0.858
Lactic acid	−0.065	0.544	0.003	0.940	−0.024	0.820	−0.021	0.630

^aMeasured at first visit only

^bLogged for modeling