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Rats that sustained bilateral injections of rAAV2-tauP301L were significantly impaired in the retention of reinforced spatial alternation performance, although not in the acquisition of the task. The Tau group committed significantly more errors (p's ≤ .035) than the GFP-injected beginning about the seventh week of testing through the end of the study in the twelfth week. (Error bars = ±S.E.M.).
