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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Neurogastroenterol Motil. 2010 Aug 16;22(12):1332–1339. doi: 10.1111/j.1365-2982.2010.01583.x

Figure 2.

Figure 2

Demonstration that evoked fEPSPs activity was inhibited by application of G. buchananii extract (0.25 - 0. 5 g bark powder/100 ml Krebs), and these actions were not mediated by opioid or alpha-2 adrenoceptor receptors. A. Representative traces of fEPSPs, demonstrating that G. buchananii extract inhibited fEPSPs in S neurons in the myenteric ganglia of guinea pig distal colon. These actions were not affected by the opioid receptor antagonist, naloxone (10 μM), or by the alpha-2 adrenoceptor antagonist, yohimbine (1 μM). B. Summary data showing that G. buchananii bark extract (0.25 g bark powder/100 ml Krebs) reduced fEPSPs amplitudes in the myenteric neurons after 5 min (bracket with triangle). The inhibitory actions of G. buchananii extract on fEPSPs persisted in the presence of the opioid receptor antagonist, naloxone (10 μM) and the alpha-2 adrenoceptor antagonist, yohimbine (1 μM) (bracket with asterisk). The fEPSPs amplitudes were restored to normal values by washout for 5-10 minutes, and were not affected by naloxone (ns bracket).