Table 3.
Prevalence of periarticular cystic lesions and cyst-like bursitis at baseline and their association with incident radiographic OA
| WORMS Grade | Incident radiographic OA |
||||
|---|---|---|---|---|---|
| Prevalence (%)at baseline |
OR (95% CI) |
||||
| Cases (N=149) | Controls (N=298) | Adjusted # | Fully Adjusted ## | ||
| Baker’s Cyst | 0 | 83 (56) | 201 (68) | 1.0 (ref) | 1.0 (ref) |
| 1 | 47 (31) | 84 (28) | 1.2 (0.8, 2.0) | 1.2 (0.7, 2.0) | |
| 2 | 16 (11) | 9 (3) | 4.1 (1.7, 10.0)* | 3.1 (1.1, 8.6)** | |
| 3 | 3 (2) | 4 (1) | 1.6 (0.3, 7.7) | 0.5 (0.1, 3.3) | |
| Meniscal Cyst$ | |||||
| Medial$$ | 0 | 149 (100) | 294 (99) | n/a | n/a |
| 1 | 0 (0) | 4 (1) | n/a | n/a | |
| Lateral$$ | 0 | 147 (99) | 298 (100) | n/a | n/a |
| 1 | 2 (1) | 0 (0) | n/a | n/a | |
| Combined | 0 | 147 (99) | 294 (99) | 1.0 (ref) | (ref) |
| 1 | 2 (1) | 4 (1) | 0.8 (0.1, 4.6) | 0.6 (0.1, 4.2) | |
| PTFJ Cyst† | 0 | 143 (96) | 294 (99) | 1.0 (ref) | 1.0 (ref) |
| 1 | 6 (4) | 3 (1) | 4.5 (1.1, 18.8)*** | 2.6 (0.5, 12.2) | |
| Prepatellar bursitis†† | 0 | 124 (85) | 265 (89) | 1.0 (ref) | 1.0 (ref) |
| 1 | 22 (15) | 33 (11) | 1.1 (0.6, 2.2) | 1.5 (0.7, 3.1) | |
| Anserine bursitis | 0 | 143 (96) | 293 (98) | 1.0 (ref) | 1.0 (ref) |
| 1 | 6 (4) | 5 (2) | 1.5 (0.4, 5.9) | 0.7 (0.1, 3.8) | |
Abbreviations: OA = osteoarthritis; PTFJ = proximal tibiofibular joint; N = total number of subjects in case and control groups; SD = standard deviation; OR = odds ratio; CI = confidence interval; WORMS = Whole Organ Magnetic Resonance Imaging Score
missing value in one control knee;
missing value in three case knees
p=0.0017,
p=0.031 and
p=0.038. Although 95% CI does not include 1.0, the results of ** and *** were not considered statistically significant after Bonferroni correction for multiple comparisons (level of significance was determined to be p<0.007).
Odds ratio were calculated after making adjustments as follows:
adjusting for age, sex, race, BMI and alignment at baseline
adjusting for age, sex, race, BMI, alignment, and other MRI features at baseline, i.e., maximum score of each feature, including BML, synovitis, joint effusion, meniscal damage, and cartilage loss
Not adjusted for meniscal damage in the fully-adjusted model
Calculation of odds ratios was not possible