Table 5.
Determinant | Overall Mortality | Relapse | NRM | Acute GVHD (II–IV) |
---|---|---|---|---|
TNF -308 | ||||
GG | 1 | 1 | 1 | 1 |
AG | 0.97 (0.74–1.28, p=.85) | 1.31 (0.89–1.91, p=.17) | 0.99 (0.71–1.36, p=.93) | 0.82 (0.51–1.33, p=.43) |
AA | 0.85 (0.40–1.83, p=.68) | 0.85 (0.27–2.74, p=.79) | 0.82 (0.33–2.01, p=.82) | 0.86 (0.24–3.05, p=.81) |
TNF -863 | ||||
CC | 1 | 1 | 1 | 1 |
AC | 1.06 (0.81–1.40, p=.67) | 1.32 (0.90–1.94, p=.16) | 0.97 (0.70–1.36, p=.87) | 0.86 (0.53–1.41, p=.56) |
AA | 1.14 (0.53–2.45, p=.74) | 0.89 (0.21–3.66, p=.87) | 1.06 (0.43–2.65, p=.89) | 0.52 (0.12–2.32, p=.39) |
DR15 | ||||
absent | 1 | 1 | 1 | 1 |
present | 0.92 (0.68–1.23, p=.55) | 0.98 (0.65–1.48, p=.91) | 0.92 (0.65–1.31, p=.65) | 1.14 (0.68–1.89, p=.63) |
Values listed are hazard (for overall mortality, relapse, NRM) or odds ratios (for GVHD) (95% CI, p-value).
CI=confidence interval; GVHD=graft-versus-host disease; NRM=non-relapse mortality; TNF=tumor necrosis factor α.